Summer is here, and you may be looking for an easy-breezy way to keep your skin healthy and hydrated. I strategically rotate ampoules for different restorative benefits, with PDRN a top pick for summer. The PDRN ampoule from K-beauty brand Dr. Esthé gives your skin everything it needs during the summer months. Use if you live in dry heat, to regenerate skin after overexposure to UV rays, or any time your skin is damaged or dehydrated. I also suggest it to clients for year-round rejuvenation and glossy skin.
Ampoule vs. Serum

Before we dive into the benefits of PDRN, let’s clarify the difference between an ampoule and a serum. Developed by innovative Korean skincare chemists, ampoules are next-level multi-serums. K-beauty brands introduced the concept of layering tailored skin treatments, but their current skincare trends lean toward utilizing multitasking products that require fewer steps to revitalize skin. Ampoules simplify and elevate your skincare routine while delivering more bang for your buck.
Skincare Serums
Serums are thin and lightweight formulas designed to sink into your skin, delivering anti-aging antioxidants deep into your pores. Moisturizing creams must be layered on top, as serums nourish, but they don’t provide enough hydration or protection to layer solo. Apply serum after cleansing and before moisturizer. During the day, layer sunscreen on top of your moisturizer, followed by makeup if you wear makeup. At night, layer moisturizer and oil.
Ampoules

Dr. Esthé Rejuvenating PDRN Ampoule is an ultra-concentrated, all-in-one super serum. It’s so powerful that it delivers the hydration and nourishment of a professional facial. Every. Single. Application. Even without PDRN, ampoules are ultra-concentrated. So, select a formulation with actives your skin needs right now. Apply after cleansing and before daytime sunscreen and makeup. In the evening, this is all you need after cleansing. You can layer more products if you want to, but with this high-performing product, you don’t have to!
Cosmeceutical PDRN
Korean skincare brands introduced the use of Polydeoxyribonucleotide (PDRN) in anti-aging topicals. It’s so powerful that it’s utilized in the medical industry as injections that accelerate wound repair. As a cosmeceutical skincare brand, Dr. Esthé incorporates ingredients scientifically proven to heal and restore skin for accelerated results. I rotate this ampoule in my personal skincare routine and apply it to my elbows and knees anytime my psoriasis flares up.

Being derived from salmon DNA, PDRN is a bit controversial. However, no salmon dies during harvesting. It’s derived from salmon sperm and can be harvested repeatedly without killing salmon. So, it’s cruelty-free, but not vegan. Once harvested, the DNA goes through a rigorous medical-grade purification and sterilization process.
Multitasking PDRN Ampoule
This ultra-concentrated formulation combines the regenerative properties of PDRN with PLLA, propolis, and a proprietary coiling polymer network to:
- Restore the skin barrier
- Regenerate damaged skin
- Nourish and hydrate
- Brighten and smooth
- Achieve glossy skin
More Bang For Your Buck

If you’re looking for one product to regenerate, repair, recover, and rejuvenate—this is it! The concentrated formulation replaces your need for serum and moisturizer. Cleanse and apply, only layering UV protection in the mornings. Layer more products when you have time, but know that you’re protecting and restoring your skin even when time is tight.
- PLLA: Poly-l-lactic acid is a biostimulator and the key component in dissolvable sutures. It prompts your body to create collagen and activates cellular regeneration and repair.
- PDRN: A powerful active that boosts hydration and promotes cell growth, tissue repair, and collagen production. It heals damaged skin barriers and brightens uneven skin.
- Propolis Extract: Harvested from bee hives, propolis is an antioxidant-rich and reparative compound that rejuvenates tired skin while minimizing fine lines and wrinkles.
- Ultra-Hydrating: This formulation is proven to increase hydration by up to 10 points in just one application. In addition to measurable hydration, it instantly restores radiance.
- Coil Polymer Network: Dr. Esthé’s PDRN all-in-one super serum creates an invisible mesh that pushes actives closer and deeper into the skin to optimize performance.
- Protective Gloss Layer: This elastic-like formula creates a smoothing film over the skin that plumps up and fills wrinkles for a desirable glass skin/glossy skin finish.
The Nutrients of a Facial Every Day

Efficacy is always my priority. Applying the facial-like nutrients in this ampoule to your skin daily helps you achieve your skincare goals faster. This elegant formula covers your entire face and neck with 2 or 3 pumps. The consistency is elastic and stretchy, but not sticky—and it doesn’t cause oil or acne.
Use morning and evening, once a day, or a few days a week. I like to apply it after using the Exoderm Mask. I often use the Time Master Pro over the Exoderm Mask, then finish with PDRN.
Why I Love This Ampoule For Summer
Summer is the time to swap heavy moisturizing creams and full-coverage makeup out for lightweight alternatives. Even if you still wear full makeup in the summer, this ampoule accelerates your skincare routine by eliminating the need for both serum and moisturizer. Its ingredient range is uniquely formulated to meet your skin's needs when the weather is hot, particularly if you live in a desert or area with dry heat. The glossy film it creates over your skin keeps your skin from getting parched, even when indoors in dry air conditioning all day.
Have fun in the sun, but don’t forget to wear a hat, seek shade, and reapply head-to-toe UV protection every 2 hours. When you forget to reapply UV protection or get sunburned, this formula helps your skin recover and repair.
Why I Love This Ampoule Year-Round
A top pick for summer, I rotate Dr. Esthé’s revitalizing PDRN in and out of my skincare routine year-round. Rotating products every 1 to 4 months keeps skin guessing in a healthy manner. This tackles anti-aging from a range of regenerative methods.
- Patch treat head-to-toe psoriasis, eczema, or redness any time of the year.
- Restore skin after laser treatments, chemical peels, or harsh skin treatments.
- Apply to protect or heal skin during or after high winds or extreme weather.
- Use to revitalize cells and recover elasticity whenever your skin barrier is damaged.
- Apply during the fall to restore and repair skin from overexposure to summer sun.
- Apply to soothe and restore after deep exfoliating and at-home facial treatments.
- Use year-round with or without makeup for glowing, gorgeous, and glossy skin.
Let’s Discuss What Ampoules Are Right For You

This PDRN super serum is one of many high-performing ampoules from Dr. Esthé. The options can be overwhelming, so let’s discuss what’s right for you! Join the Christine Byer Beauty Club to learn how to tailor your summer and year-round skincare routine for your local climate, lifestyle, skin type, and skin conditions.
I offer a 14-Day FREE preview with full access to everything in the Club. This includes answers to seasonal skin care questions and access to exclusive content and discounts. If you don’t find value in your membership, cancel within 14 days at no charge.